Cell reprogramming for skeletal dysplasia drug repositioning
نویسندگان
چکیده
منابع مشابه
Network mirroring for drug repositioning
BACKGROUND Although drug discoveries can provide meaningful insights and significant enhancements in pharmaceutical field, the longevity and cost that it takes can be extensive where the success rate is low. In order to circumvent the problem, there has been increased interest in 'Drug Repositioning' where one searches for already approved drugs that have high potential of efficacy when applied...
متن کاملDrug repositioning for orphan diseases
The need and opportunity to discover therapeutics for rare or orphan diseases are enormous. Due to limited prevalence and/or commercial potential, of the approximately 6000 orphan diseases (defined by the FDA Orphan Drug Act as <200 000 US prevalence), only a small fraction (5%) is of interest to the biopharmaceutical industry. The fact that drug development is complicated, time-consuming and e...
متن کاملDrug Repositioning in Cancer
The development of new therapeutic agents, in any kind of disease, requires either long time or high costs; indeed 10 15 years of research are required to market a drug, resulting in an overall cost of about 1.8 billion dollars [1]. In addition, drug development in oncology is very challenging due to cancer biological complexity, actually comprising several subtypes of diseases carrying differe...
متن کاملMeSHDD: Literature-based drug-drug similarity for drug repositioning
Objective Drug repositioning is a promising methodology for reducing the cost and duration of the drug discovery pipeline. We sought to develop a computational repositioning method leveraging annotations in the literature, such as Medical Subject Heading (MeSH) terms. Methods We developed software to determine significantly co-occurring drug-MeSH term pairs and a method to estimate pair-wise ...
متن کاملA standard database for drug repositioning
Drug repositioning, the process of discovering, validating, and marketing previously approved drugs for new indications, is of growing interest to academia and industry due to reduced time and costs associated with repositioned drugs. Computational methods for repositioning are appealing because they putatively nominate the most promising candidate drugs for a given indication. Comparing the wi...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2014
ISSN: 1538-4101,1551-4005
DOI: 10.4161/15384101.2014.989944